The effect of multidrug-resistant infections in cancer hospital intensive care unit

Abstract

AbstractBackground: For millennia, health-care-associated infections (HAI) have had a negative impact on healthcare systems. Multidrug-resistant Infections (MDRI) have exacerbated the issue in recent years, owing to the abuse of standard antibiotics in dealing with bacterial infection concerns. The bacteria show adaptability in hostile living conditions by resisting most known antibiotics and their combinations. This imposes a new burden on the hospital's health care, especially for patients in the ICU. This risk is amplified when considering, cancer patients who are at greater risk of serious sepsis, Hospital acquired infection (HAI), and with a multi-drug resistant bacterium (MDRB). This is a global issue which needs to be addressed and should have a clear health policy to tackle this problem.Objective: The goal of this study was to identify the infectious diseases', microbial and antibiotic resistance profiles, and their impact on the mortality of multi-drug resistant (MDR) infections in a range of distinct locales throughout the world.Materials and Methods: A 5-year retrospective descripted HAI study on patients at the Mexican Oncology Center Intensive Care Unit was carried out from January 2007 until December 2011. Patient features and co-morbidities, the tumor and treatment data, microbiology, and patterns of pharmaceutical resistance of all isolates have been collected.Results and Discussions: 1418 patients were treated by the intensive care unit during the study period, with 159 of them occurring every 3000 23.2 days in 134 infections with a frequency of 11.2 % of workers. There were 266 types of microorganisms. MDR-HAI 's gross incidence was 39.5%. The most common microorganisms are: 54 (20%) Escherichia Coli (94%); 32 (12%) Staphylococcus aureus (90% are methicillin-resistant); 32 (12%) Enterococcus faecal (18.7% are vancomycin-resistant); and 20 (6%) Acinetobacter baumanni (both MDR). Microorganisms among the most popular are 252 (17.8 percent) of patients who were treated in intensive care died. Of the 58 (23%) HAI patients died and 51 (88%) were MDR isolated (p = 0.05) patients.Conclusion: The production of MDR bacteria is a daunting challenge for clinicians with inadequate treatment possibilities. The risk of developing bacterium MDR-HAI, which has a negative effect on survival, is high for serious cancer patients in intensive care. [Ethiop. J. Health Dev. 2021; 35(3): 220-226]Keywords: Health Care-associated Infections (HAI), ICU, oncology, multi-drug resistant bacteria (MDRB), Antibiotics